LymphedemaV1, Main, Exploration, bibRecord, 001D60

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Identifieur interne : 001D60 ( Main/Exploration ); précédent : 001D59; suivant : 001D61

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Auteurs : M Guy Roukens ; Josi Peterson-Maduro ; Yvonne Padberg ; Michael Jeltsch ; Veli-Matti Lepp Nen ; Frank L. Bos ; Kari Alitalo [Finlande] ; Stefan Schulte-Merker ; Dörte Schulte [Allemagne]

Source :

Circulation research [ 1524-4571 ] ; 2015.

RBID : pubmed:25814692

Descripteurs français

English descriptors

KwdEn :
- Animals, Binding Sites, Calcium-Binding Proteins (chemistry), Calcium-Binding Proteins (deficiency), Calcium-Binding Proteins (genetics), Calcium-Binding Proteins (metabolism), Collagen (metabolism), Craniofacial Abnormalities (genetics), Craniofacial Abnormalities (metabolism), Endothelial Cells (metabolism), Epidermal Growth Factor (metabolism), Gene Expression Regulation, Developmental, Gene Knock-In Techniques, Genital Diseases, Male (genetics), Genital Diseases, Male (metabolism), Genotype, Gestational Age, HEK293 Cells, Humans, Lymphangiectasis, Intestinal (genetics), Lymphangiectasis, Intestinal (metabolism), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Lymphedema (genetics), Lymphedema (metabolism), Mice, Mice, Transgenic, Mutation, Phenotype, Protein Binding, Protein Interaction Domains and Motifs, Signal Transduction, Transfection, Tumor Suppressor Proteins (chemistry), Tumor Suppressor Proteins (deficiency), Tumor Suppressor Proteins (genetics), Tumor Suppressor Proteins (metabolism), Vascular Endothelial Growth Factor C (metabolism), Zebrafish (genetics), Zebrafish (metabolism), Zebrafish Proteins (chemistry), Zebrafish Proteins (genetics), Zebrafish Proteins (metabolism).
MESH :
- chemical , chemistry : Calcium-Binding Proteins, Tumor Suppressor Proteins, Zebrafish Proteins.
- chemical , deficiency : Calcium-Binding Proteins, Tumor Suppressor Proteins.
- chemical , genetics : Calcium-Binding Proteins, Tumor Suppressor Proteins, Zebrafish Proteins.
- chemical , metabolism : Calcium-Binding Proteins, Collagen, Epidermal Growth Factor, Tumor Suppressor Proteins, Vascular Endothelial Growth Factor C, Zebrafish Proteins.
- embryology : Lymphatic Vessels.
- genetics : Craniofacial Abnormalities, Genital Diseases, Male, Lymphangiectasis, Intestinal, Lymphedema, Zebrafish.
- metabolism : Craniofacial Abnormalities, Endothelial Cells, Genital Diseases, Male, Lymphangiectasis, Intestinal, Lymphatic Vessels, Lymphedema, Zebrafish.
- Animals, Binding Sites, Gene Expression Regulation, Developmental, Gene Knock-In Techniques, Genotype, Gestational Age, HEK293 Cells, Humans, Mice, Mice, Transgenic, Mutation, Phenotype, Protein Binding, Protein Interaction Domains and Motifs, Signal Transduction, Transfection.

Abstract

Collagen- and calcium-binding EGF domain-containing protein 1 (CCBE1) is essential for lymphangiogenesis in vertebrates and has been associated with Hennekam syndrome. Recently, CCBE1 has emerged as a crucial regulator of vascular endothelial growth factor-C (VEGFC) signaling.

DOI: 10.1161/CIRCRESAHA.116.304949
PubMed: 25814692

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.</title>
<author><name sortKey="Roukens, M Guy" sort="Roukens, M Guy" uniqKey="Roukens M" first="M Guy" last="Roukens">M Guy Roukens</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
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<author><name sortKey="Peterson Maduro, Josi" sort="Peterson Maduro, Josi" uniqKey="Peterson Maduro J" first="Josi" last="Peterson-Maduro">Josi Peterson-Maduro</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
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<author><name sortKey="Padberg, Yvonne" sort="Padberg, Yvonne" uniqKey="Padberg Y" first="Yvonne" last="Padberg">Yvonne Padberg</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
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<author><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
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<author><name sortKey="Lepp Nen, Veli Matti" sort="Lepp Nen, Veli Matti" uniqKey="Lepp Nen V" first="Veli-Matti" last="Lepp Nen">Veli-Matti Lepp Nen</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
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<author><name sortKey="Bos, Frank L" sort="Bos, Frank L" uniqKey="Bos F" first="Frank L" last="Bos">Frank L. Bos</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
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<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
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<author><name sortKey="Schulte, Dorte" sort="Schulte, Dorte" uniqKey="Schulte D" first="Dörte" last="Schulte">Dörte Schulte</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.). d.schulte@uni-muenster.de.</nlm:affiliation>
<country wicri:rule="url">Allemagne</country>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.</title>
<author><name sortKey="Roukens, M Guy" sort="Roukens, M Guy" uniqKey="Roukens M" first="M Guy" last="Roukens">M Guy Roukens</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Peterson Maduro, Josi" sort="Peterson Maduro, Josi" uniqKey="Peterson Maduro J" first="Josi" last="Peterson-Maduro">Josi Peterson-Maduro</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Padberg, Yvonne" sort="Padberg, Yvonne" uniqKey="Padberg Y" first="Yvonne" last="Padberg">Yvonne Padberg</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lepp Nen, Veli Matti" sort="Lepp Nen, Veli Matti" uniqKey="Lepp Nen V" first="Veli-Matti" last="Lepp Nen">Veli-Matti Lepp Nen</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bos, Frank L" sort="Bos, Frank L" uniqKey="Bos F" first="Frank L" last="Bos">Frank L. Bos</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name>
<affiliation><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).</nlm:affiliation>
<wicri:noCountry code="subField">D.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Schulte, Dorte" sort="Schulte, Dorte" uniqKey="Schulte D" first="Dörte" last="Schulte">Dörte Schulte</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.). d.schulte@uni-muenster.de.</nlm:affiliation>
<country wicri:rule="url">Allemagne</country>
</affiliation>
</author>
</analytic>
<series><title level="j">Circulation research</title>
<idno type="eISSN">1524-4571</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Binding Sites</term>
<term>Calcium-Binding Proteins (chemistry)</term>
<term>Calcium-Binding Proteins (deficiency)</term>
<term>Calcium-Binding Proteins (genetics)</term>
<term>Calcium-Binding Proteins (metabolism)</term>
<term>Collagen (metabolism)</term>
<term>Craniofacial Abnormalities (genetics)</term>
<term>Craniofacial Abnormalities (metabolism)</term>
<term>Endothelial Cells (metabolism)</term>
<term>Epidermal Growth Factor (metabolism)</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Gene Knock-In Techniques</term>
<term>Genital Diseases, Male (genetics)</term>
<term>Genital Diseases, Male (metabolism)</term>
<term>Genotype</term>
<term>Gestational Age</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Lymphangiectasis, Intestinal (genetics)</term>
<term>Lymphangiectasis, Intestinal (metabolism)</term>
<term>Lymphatic Vessels (embryology)</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphedema (genetics)</term>
<term>Lymphedema (metabolism)</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Mutation</term>
<term>Phenotype</term>
<term>Protein Binding</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Signal Transduction</term>
<term>Transfection</term>
<term>Tumor Suppressor Proteins (chemistry)</term>
<term>Tumor Suppressor Proteins (deficiency)</term>
<term>Tumor Suppressor Proteins (genetics)</term>
<term>Tumor Suppressor Proteins (metabolism)</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
<term>Zebrafish (genetics)</term>
<term>Zebrafish (metabolism)</term>
<term>Zebrafish Proteins (chemistry)</term>
<term>Zebrafish Proteins (genetics)</term>
<term>Zebrafish Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules HEK293</term>
<term>Cellules endothéliales (métabolisme)</term>
<term>Collagène (métabolisme)</term>
<term>Danio zébré (génétique)</term>
<term>Danio zébré (métabolisme)</term>
<term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term>
<term>Facteur de croissance épidermique (métabolisme)</term>
<term>Génotype</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lymphangiectasie intestinale (génétique)</term>
<term>Lymphangiectasie intestinale (métabolisme)</term>
<term>Lymphoedème (génétique)</term>
<term>Lymphoedème (métabolisme)</term>
<term>Maladies de l'appareil génital mâle (génétique)</term>
<term>Maladies de l'appareil génital mâle (métabolisme)</term>
<term>Malformations crâniofaciales (génétique)</term>
<term>Malformations crâniofaciales (métabolisme)</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Protéines de liaison au calcium ()</term>
<term>Protéines de liaison au calcium (déficit)</term>
<term>Protéines de liaison au calcium (génétique)</term>
<term>Protéines de liaison au calcium (métabolisme)</term>
<term>Protéines de poisson-zèbre ()</term>
<term>Protéines de poisson-zèbre (génétique)</term>
<term>Protéines de poisson-zèbre (métabolisme)</term>
<term>Protéines suppresseurs de tumeurs ()</term>
<term>Protéines suppresseurs de tumeurs (déficit)</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Protéines suppresseurs de tumeurs (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Sites de fixation</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Techniques de knock-in de gènes</term>
<term>Transduction du signal</term>
<term>Transfection</term>
<term>Vaisseaux lymphatiques (embryologie)</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
<term>Âge gestationnel</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium-Binding Proteins</term>
<term>Tumor Suppressor Proteins</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Calcium-Binding Proteins</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium-Binding Proteins</term>
<term>Tumor Suppressor Proteins</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium-Binding Proteins</term>
<term>Collagen</term>
<term>Epidermal Growth Factor</term>
<term>Tumor Suppressor Proteins</term>
<term>Vascular Endothelial Growth Factor C</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Protéines de liaison au calcium</term>
<term>Protéines suppresseurs de tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Craniofacial Abnormalities</term>
<term>Genital Diseases, Male</term>
<term>Lymphangiectasis, Intestinal</term>
<term>Lymphedema</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Danio zébré</term>
<term>Lymphangiectasie intestinale</term>
<term>Lymphoedème</term>
<term>Maladies de l'appareil génital mâle</term>
<term>Malformations crâniofaciales</term>
<term>Protéines de liaison au calcium</term>
<term>Protéines de poisson-zèbre</term>
<term>Protéines suppresseurs de tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Craniofacial Abnormalities</term>
<term>Endothelial Cells</term>
<term>Genital Diseases, Male</term>
<term>Lymphangiectasis, Intestinal</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term>
<term>Collagène</term>
<term>Danio zébré</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Facteur de croissance épidermique</term>
<term>Lymphangiectasie intestinale</term>
<term>Lymphoedème</term>
<term>Maladies de l'appareil génital mâle</term>
<term>Malformations crâniofaciales</term>
<term>Protéines de liaison au calcium</term>
<term>Protéines de poisson-zèbre</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Binding Sites</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Gene Knock-In Techniques</term>
<term>Genotype</term>
<term>Gestational Age</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Mutation</term>
<term>Phenotype</term>
<term>Protein Binding</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Signal Transduction</term>
<term>Transfection</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules HEK293</term>
<term>Génotype</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Protéines de liaison au calcium</term>
<term>Protéines de poisson-zèbre</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Sites de fixation</term>
<term>Souris</term>
<term>Souris transgéniques</term>
<term>Techniques de knock-in de gènes</term>
<term>Transduction du signal</term>
<term>Transfection</term>
<term>Âge gestationnel</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Collagen- and calcium-binding EGF domain-containing protein 1 (CCBE1) is essential for lymphangiogenesis in vertebrates and has been associated with Hennekam syndrome. Recently, CCBE1 has emerged as a crucial regulator of vascular endothelial growth factor-C (VEGFC) signaling.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Finlande</li>
</country>
<region><li>Uusimaa</li>
</region>
<settlement><li>Helsinki</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Bos, Frank L" sort="Bos, Frank L" uniqKey="Bos F" first="Frank L" last="Bos">Frank L. Bos</name>
<name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name>
<name sortKey="Lepp Nen, Veli Matti" sort="Lepp Nen, Veli Matti" uniqKey="Lepp Nen V" first="Veli-Matti" last="Lepp Nen">Veli-Matti Lepp Nen</name>
<name sortKey="Padberg, Yvonne" sort="Padberg, Yvonne" uniqKey="Padberg Y" first="Yvonne" last="Padberg">Yvonne Padberg</name>
<name sortKey="Peterson Maduro, Josi" sort="Peterson Maduro, Josi" uniqKey="Peterson Maduro J" first="Josi" last="Peterson-Maduro">Josi Peterson-Maduro</name>
<name sortKey="Roukens, M Guy" sort="Roukens, M Guy" uniqKey="Roukens M" first="M Guy" last="Roukens">M Guy Roukens</name>
<name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name>
</noCountry>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
</region>
</country>
<country name="Allemagne"><noRegion><name sortKey="Schulte, Dorte" sort="Schulte, Dorte" uniqKey="Schulte D" first="Dörte" last="Schulte">Dörte Schulte</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

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